https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Towards a framework for better understanding of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45157 Wed 26 Oct 2022 13:54:59 AEDT ]]> A p53-responsive miRNA network promotes cancer cell quiescence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35745 chromosome 9 open reading frame 3 gene that was transcriptionally activated by p53. Similarly, the host gene of miRNA-455-3p, collagen alpha-1 (XXVII) chain, was also a p53 transcriptional target. Collectively, our results identify miRNA-27b-3p and miRNA-455-3p as important regulators of cancer cell quiescence in response to p53 and suggest that manipulating miRNA-27b-3p and miRNA-455-3p may constitute novel therapeutic avenues for improving outcomes of cancer treatment. Significance: Two novel p53-responsive microRNAs whose distinct mechanisms of action both stabilize p27 to promote cell quiescence and may serve as therapeutic avenues for improving outcomes of cancer treatment.]]> Thu 28 Oct 2021 12:36:09 AEDT ]]> Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45318 Thu 27 Oct 2022 13:56:46 AEDT ]]> Molecular characterization of quiescent cancer cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35744 Thu 14 Nov 2019 16:52:07 AEDT ]]>